Ver el código de «JAG1»

{{Ficha de proteína
|Name=jagged
|caption=
|image=
|width=
|HGNCid=6188
|Símbolo=JAG1
|AltSymbols=AGS, JAGL1
|OMIM=601920
 | Homologene = 180
 | GeneAtlas_image1 = PBB_GE_JAG1_216268_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_JAG1_209097_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_JAG1_209098_s_at_tn.png
|Varios_PDB={{PDB2|2KB9}}, {{PDB2|2VJ2}}
|ECnumber=
|Cromosoma=20
|Brazo=p
|Banda=12.1
|LocusSupplementaryData=-11.23
 | Hs_EntrezGene = 182
 | Hs_Ensembl = ENSG00000101384
 | Hs_RefseqmRNA = NM_000214
 | Hs_RefseqProtein = NP_000205
 | Hs_GenLoc_db = hg19
 | Hs_GenLoc_chr = 20
 | Hs_GenLoc_start = 10618332
 | Hs_GenLoc_end = 10654608
 | Hs_Uniprot = P78504
 | Mm_EntrezGene = 16449
 | Mm_Ensembl = ENSMUSG00000027276
 | Mm_RefseqmRNA = NM_013822
 | Mm_RefseqProtein = NP_038850
 | Mm_GenLoc_db = mm9
 | Mm_GenLoc_chr = 2
 | Mm_GenLoc_start = 137081456
 | Mm_GenLoc_end = 137116644
 | Mm_Uniprot = Q9QXX0
}}
'''JAG1''', también conocido como '''CD339''' ([[cúmulo de diferenciación]] 339).
es un [[gen]] localizado en el brazo corto del [[cromosoma 20]], en humanos. Codifica para una [[proteína]] homómina de 1.218 [[aminoácido]]s y 133,8 [[Unidad de masa atómica|kDa]]. El gen comienza a expresarse entre las primeras 32-42 semanas del [[embriogénesis|desarrollo embrionario]]. Defectos en este gen se relacionan con el [[síndrome de Alagille]].<ref>{{cita web|url=http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=182|título=Entrez Gene: JAG1 jagged 1 (Alagille syndrome)|fechaacceso=6 de mayo de 2014|idioma=inglés}}</ref><ref name=pmid11346656>{{cite journal |last=Shimizu |first=K |authorlink= | autor2 = Chiba S| autor3 =  Saito T| autor4 =  Kumano K| autor5 =  Takahashi T| autor6 =  Hirai H |date=July 2001  |title=Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation |journal=J. Biol. Chem. |volume=276 |issue=28 |pages=25753–8 |publisher= |location = United States| issn = 0021-9258| pmid = 11346656 |doi = 10.1074/jbc.M103473200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10551863>{{cite journal |last=Shimizu |first=K |authorlink= | autor2 = Chiba S| autor3 =  Kumano K| autor4 =  Hosoya N| autor5 =  Takahashi T| autor6 =  Kanda Y| autor7 =  Hamada Y| autor8 =  Yazaki Y| autor9 =  Hirai H |date=November 1999  |title=Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods |journal=J. Biol. Chem. |volume=274 |issue=46 |pages=32961–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10551863 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.46.32961 }}</ref><ref name=pmid10958687>{{cite journal |last=Shimizu |first=K |authorlink= | autor2 = Chiba S| autor3 =  Hosoya N| autor4 =  Kumano K| autor5 =  Saito T| autor6 =  Kurokawa M| autor7 =  Kanda Y| autor8 =  Hamada Y| autor9 =  Hirai H |date=September 2000  |title=Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 |journal=Mol. Cell. Biol. |volume=20 |issue=18 |pages=6913–22 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10958687 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.20.18.6913-6922.2000 |pmc=88767 }}</ref>

== Referencias ==
{{listaref|2}}

{{Control de autoridades}}
[[Categoría:Proteínas]]